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Vaccines can blunt the deadly synthetic opioid effect

February 5, 2021 – New experimental vaccines can stop the worst effects of Fentanyl and Synthetic Carfentanil, two drugs that have become the main driver of the opioid epidemic at A.S., according to a new study published in ACS Chemical Biology on Wednesday.

During several experiments in mice, vaccines prevent respiratory depression, which are the main causes of death overdose. Vaccines also reduce the number of drugs distributed to the brain. After in the brain, synthetic opioids push the body to slow breathing, and when too many drugs are consumed, breathing can stop.

Synthetic opioids are not only very deadly but are also addictive and easy to produce, making it a form of public health threats, especially when the Coronavirus crisis has a negative impact on mental health,” Kim widow, PhD, a chemist at the Scripps Research Institute in California who developed a vaccine , said in a statement.

Fentanyl is up to 100 times stronger than morphine, and carfentanil, which is often used by veterinarians to soothe large animals such as elephants, up to 10,000 times stronger than morphine. Carfentanil is not known as a street medicine, but it is used more often as an additive in heroin and cocaine.

“We have shown that it is possible to prevent this unnecessary death by raising antibodies that stop the drug from reaching the brain,” he said.

This vaccine can be used in emergency situations to treat overdoses and as therapy for those who have substance abuse disorders, widows. In addition, vaccines can protect military officers exposed to opioids as chemical weapons, and they can also help the police’s opioids to practice for the work.

Vaccines are still in the early stages of testing, but the latest data “gives us hope that this approach will work to treat a number of opioid related diseases,” Widow said.

In December, the CDC reported that more than 81,000 drug overdose deaths occurred in May 2019 and May 2020, which was the highest number ever recorded in a 12-month period. Synthetic opioids, especially those made illegally Fentanyl, must be blamed.

“Unfortunately, the increase in overdose incidents of Carfentanil and Fentanyl put further pressure on the public health system that was overwhelmed and now fought against a pandemic,” Widow said. “We hope to continue our vaccine research and translate it to the clinic, where we can begin to have an impact on the opioid crisis.”